Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lysosomal processing of progranulin.

Molecular neurodegeneration - 23 Aug 2017

Zhou Xiaolai, Paushter Daniel H, Feng Tuancheng, Sun Lirong, Reinheckel Thomas, Hu Fenghua

Abstract excerpt

BACKGROUND: Mutations resulting in progranulin (PGRN) haploinsufficiency cause frontotemporal lobar degeneration with TDP-43-positive inclusions (FTLD-TDP), a devastating neurodegenerative disease. PGRN is localized to the lysosome and important for proper lysosome function. However, the metabolism of PGRN in the lysosome is still unclear. RESULTS: Here, we report that PGRN is processed into ~10 kDa peptides...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cathepsins
Share to Disease Models, Animal
Share to Frontotemporal Lobar Degeneration

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Haploinsufficiency

Share to Intercellular Signaling Peptides and Proteins

Share to Lysosomes

Share to Mice, Knockout

Share to Progranulins

Source

Open in PubMed Open full text

Identifiers

PMID: 28835281
DOI: 10.1186/s13024-017-0205-9
PMCID: PMC5569495

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lysosomal processing of progranulin.PMID 28835281Read ↗

Processing of progranulin into granulins involves multiple lysosomal proteases and is affected in frontotemporal lobar degenerationSemantic proximity Read ↗

The lysosomal function of progranulin, a guardian against neurodegeneration.Semantic proximity Read ↗

Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes.Semantic proximity Read ↗

Lysosomal Dysfunction and Other Pathomechanisms in FTLD: Evidence from Progranulin Genetics and Biology.Semantic proximity Read ↗

Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin.Semantic proximity Read ↗

Progranulin-mediated deficiency of cathepsin D results in FTD and NCL-like phenotypes in neurons derived from FTD patients.Semantic proximity Read ↗

Lipidomic and Transcriptomic Basis of Lysosomal Dysfunction in Progranulin DeficiencySemantic proximity Read ↗

Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations.Semantic proximity Read ↗

Potential mechanisms of progranulin-deficient FTLD.Semantic proximity Read ↗

Loss of TMEM106B and PGRN leads to severe lysosomal abnormalities and neurodegeneration in miceSemantic proximity Read ↗

Multi-modal Proteomic Characterization of Lysosomal Function and Proteostasis in Progranulin-Deficient NeuronsSemantic proximity Read ↗

Discovery of a protein uptake pathway in lysosomesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.