Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations.

Nature communications - 25 May 2017

Zhou Xiaolai, Sun Lirong, Bracko Oliver, Choi Ji Whae, Jia Yan, Nana Alissa L, Brady Owen Adam, Hernandez Jean C Cruz, Nishimura Nozomi, Seeley William W, Hu Fenghua

Abstract excerpt

Haploinsufficiency of progranulin (PGRN) due to mutations in the granulin (GRN) gene causes frontotemporal lobar degeneration (FTLD), and complete loss of PGRN leads to a lysosomal storage disorder, neuronal ceroid lipofuscinosis (NCL). Accumulating evidence suggests that PGRN is essential for proper lysosomal function, but the precise mechanisms involved are not known. Here, we show that PGRN facilitates...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Vesicular Transport
Share to Frontotemporal Lobar Degeneration

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Haploinsufficiency

Share to Intercellular Signaling Peptides and Proteins

Share to Lysosomes

Share to Neuronal Ceroid-Lipofuscinoses

Share to Progranulins

Share to Protein Transport

Source

Open in PubMed Open full text

Identifiers

PMID: 28541286
DOI: 10.1038/ncomms15277
PMCID: PMC5477518

Genes

PSAP
GRN
NCL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations.PMID 28541286Read ↗

The lysosomal function of progranulin, a guardian against neurodegeneration.Semantic proximity Read ↗

Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin.Semantic proximity Read ↗

Lysosomal Dysfunction and Other Pathomechanisms in FTLD: Evidence from Progranulin Genetics and Biology.Semantic proximity Read ↗

Progranulin mutations result in impaired processing of prosaposin and reduced glucocerebrosidase activitySemantic proximity Read ↗

Progranulin-mediated deficiency of cathepsin D results in FTD and NCL-like phenotypes in neurons derived from FTD patients.Semantic proximity Read ↗

Loss of Progranulin Results in Increased Pan-Cathepsin Activity and Reduced LAMP1 Lysosomal ProteinSemantic proximity Read ↗

Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis.Semantic proximity Read ↗

Progranulin: a proteolytically processed protein at the crossroads of inflammation and neurodegeneration.Semantic proximity Read ↗

Progranulin deficiency leads to reduced glucocerebrosidase activitySemantic proximity Read ↗

Progranulin deficiency leads to reduced glucocerebrosidase activitySemantic proximity Read ↗

Loss of Lysosomal Proteins Progranulin and Prosaposin Associated with Increased Neurofibrillary Tangle Development in Alzheimer Disease.Semantic proximity Read ↗

Progranulin deficiency results in reduced bis(monoacylglycero)phosphate (BMP) levels and gangliosidosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.