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Article

Katanin maintains meiotic metaphase chromosome alignment and spindle structure in vivo and has multiple effects on microtubules in vitro.

Molecular biology of the cell - 1 Apr 2014

McNally Karen, Berg Evan, Cortes Daniel B, Hernandez Veronica, Mains Paul E, McNally Francis J

Abstract excerpt

Assembly of Caenorhabditis elegans female meiotic spindles requires both MEI-1 and MEI-2 subunits of the microtubule-severing ATPase katanin. Strong loss-of-function mutants assemble apolar intersecting microtubule arrays, whereas weaker mutants assemble bipolar meiotic spindles that are longer t...

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Identifiers

PMID: 24501424
DOI: 10.1091/mbc.E13-12-0764
PMCID: PMC3967969

Genes

ASPM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24501424-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Katanin maintains meiotic metaphase chromosome alignment and spindle structure in vivo and has multiple effects on microtubules in vitro.PMID 24501424Read ↗

The spindle assembly function of Caenorhabditis elegans katanin does not require microtubule-severing activity.Semantic proximity Read ↗

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