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Article

The spindle assembly function of Caenorhabditis elegans katanin does not require microtubule-severing activity.

Molecular biology of the cell - 1 May 2011

McNally Karen Perry, McNally Francis J

Abstract excerpt

Katanin is a heterodimeric microtubule-severing protein that is conserved among eukaryotes. Loss-of-function mutations in the Caenorhabditis elegans katanin catalytic subunit, MEI-1, cause specific defects in female meiotic spindles. To determine the relationship between katanin's microtubule-severing activity and its role in meiotic spindle formation, we analyzed the MEI-1(A338S) mutant. Unlike wild-type MEI-1,...

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Identifiers

PMID: 21372175
DOI: 10.1091/mbc.E10-12-0951
PMCID: PMC3084677

Genes

ASPM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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