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Article

Differential contributions of β-tubulin isotypes to acentrosomal oocyte meiosis in C. elegans.

The Journal of cell biology - 5 Oct 2026

Nsamba Emmanuel T, Villeneuve Anne M

Abstract excerpt

Oocyte meiotic spindles must achieve bipolarity and segregate chromosomes in the absence of centrosomes. Here, we use high-resolution immunofluorescence microscopy and live imaging to investigate the differential contributions of β-tubulin isotypes (TBB-1 and TBB-2) to assembly and function of acentrosomal spindles in Caenorhabditis elegans oocytes. By combining strains with altered β-tubulin isotype composition...

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Identifiers

PMID: 42573477
DOI: 10.1083/jcb.202511199
PMCID: PMC13455592

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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