Article
SUMO-modification and elimination of the active DNA demethylation enzyme TDG in cultured human cells.
Biochemical and biophysical research communications - 9 May 2014
Moriyama Taishi, Fujimitsu Yuka, Yoshikai Yushi, Sasano Takashi, Yamada Koji, Murakami Masataka, Urano Takeshi, Sugasawa Kaoru, Saitoh Hisato
Abstract excerpt
Thymine DNA glycosylase (TDG) is a base excision repair enzyme that interacts with the small ubiquitin-related modifier (SUMO)-targeted ubiquitin E3 ligase RNF4 and functions in the active DNA demethylation pathway. Here we showed that both SUMOylated and non-modified forms of endogenous TDG fluctuated during the cell cycle and in response to drugs that perturbed cell cycle progression, including hydroxyurea and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.