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Article

A germline polymorphism of thymine DNA glycosylase induces genomic instability and cellular transformation.

PLoS genetics - 1 Nov 2014

Sjolund Ashley, Nemec Antonia A, Paquet Nicolas, Prakash Aishwarya, Sung Patrick, Doublié Sylvie, Sweasy Joann B

Abstract excerpt

Thymine DNA glycosylase (TDG) functions in base excision repair, a DNA repair pathway that acts in a lesion-specific manner to correct individual damaged or altered bases. TDG preferentially catalyzes the removal of thymine and uracil paired with guanine, and is also active on 5-fluorouracil (5-F...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genomic Instability

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Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 25375110
DOI: 10.1371/journal.pgen.1004753
PMCID: PMC4222680

Genes

TDG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25375110-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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