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Article

Unconventional Targeting of a Thiol Peroxidase to the Mitochondrial Intermembrane Space Facilitates Oxidative Protein Folding.

Cell reports - 14 Mar 2017

Kritsiligkou Paraskevi, Chatzi Afroditi, Charalampous Georgia, Mironov Aleksandr, Grant Chris M, Tokatlidis Kostas

Abstract excerpt

Thiol peroxidases are conserved hydrogen peroxide scavenging and signaling molecules that contain redox-active cysteine residues. We show here that Gpx3, the major H2O2 sensor in yeast, is present in the mitochondrial intermembrane space (IMS), where it serves a compartment-specific role in oxidative metabolism. The IMS-localized Gpx3 contains an 18-amino acid N-terminally extended form encoded from a non-AUG...

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Identifiers

PMID: 28297675
DOI: 10.1016/j.celrep.2017.02.053
PMCID: PMC5368413

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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