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Article

Parkinsonism-associated protein DJ-1 is a bona fide deglycase.

Biochemical and biophysical research communications - 29 Jan 2017

Richarme Gilbert, Dairou Julien

Abstract excerpt

We discovered recently that Parkinsonism-associated DJ-1 and its bacterial homologs function as protein deglycases that repair glyoxal- and methylglyoxal-glycated proteins. Protein glycation levels are 2- to 10-fold increased in deglycase-depleted cells, and deglycase mutants display up to 500-fold loss of viability in methylglyoxal or glucose-containing media, suggesting that these deglycases play important...

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Source

Identifiers

PMID: 28013050
DOI: 10.1016/j.bbrc.2016.12.134

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Parkinsonism-associated protein DJ-1 is a bona fide deglycase.PMID 28013050Read ↗

Evidence Against a Role for the Parkinsonism-associated Protein DJ-1 in Methylglyoxal DetoxificationSemantic proximity Read ↗

Parkinson's disease-related DJ-1 functions in thiol quality control against aldehyde attack in vitro.Semantic proximity Read ↗

<i>Saccharomyces cerevisiae</i> DJ-1 paralogs maintain genome integrity through glycation repair of nucleic acids and proteinsSemantic proximity Read ↗

Robust glyoxalase activity of Hsp31, a ThiJ/DJ-1/PfpI family member protein, is critical for oxidative stress resistance in Saccharomyces cerevisiae.Semantic proximity Read ↗

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Human DJ-1 and its homologs are novel glyoxalasesSemantic proximity Read ↗

C Terminus of DJ-1 Determines Its Homodimerization, Deglycation Activity and Suppression of FerroptosisSemantic proximity Read ↗

Reduced anti-oxidative stress activities of DJ-1 mutants found in Parkinson's disease patients.Semantic proximity Read ↗

Bacterial Responses to Glyoxal and Methylglyoxal: Reactive Electrophilic SpeciesSemantic proximity Read ↗

YajL, prokaryotic homolog of parkinsonism-associated protein DJ-1, functions as a covalent chaperone for thiol proteome.Semantic proximity Read ↗

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Products of the Parkinson’s-disease related glyoxalase DJ-1, D-lactate and glycolate, support mitochondrial membrane potential and neuronal survivalSemantic proximity Read ↗

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