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Characterization of the FKBP12-Encoding Genes in Aspergillus fumigatus

14 Sept 2015

Abstract excerpt

Invasive aspergillosis, largely caused by Aspergillus fumigatus, is responsible for a growing number of deaths among immunosuppressed patients. Immunosuppressants such as FK506 (tacrolimus) that target calcineurin have shown promise for antifungal drug development. FK506-binding proteins (FKBPs) form a complex with calcineurin in the presence of FK506 (FKBP12-FK506) and inhibit calcineurin activity. Research on...

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PMID: 26366742
DOI: 10.1371/journal.pone.0137869

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Characterization of the FKBP12-Encoding Genes in Aspergillus fumigatusPMID 26366742Read ↗

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