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Article

Antifungal drug resistance evoked via RNAi-dependent epimutations.

Nature - 25 Sept 2014

Calo Silvia, Shertz-Wall Cecelia, Lee Soo Chan, Bastidas Robert J, Nicolás Francisco E, Granek Joshua A, Mieczkowski Piotr, Torres-Martínez Santiago, Ruiz-Vázquez Rosa M, Cardenas Maria E, Heitman Joseph

Abstract excerpt

Microorganisms evolve via a range of mechanisms that may include or involve sexual/parasexual reproduction, mutators, aneuploidy, Hsp90 and even prions. Mechanisms that may seem detrimental can be repurposed to generate diversity. Here we show that the human fungal pathogen Mucor circinelloides develops spontaneous resistance to the antifungal drug FK506 (tacrolimus) via two distinct mechanisms. One involves...

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Identifiers

PMID: 25079329
DOI: 10.1038/nature13575
PMCID: PMC4177005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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