Article

Structure-guided synthesis of FK506 and FK520 analogs with increased selectivity exhibit in vivo therapeutic efficacy against Cryptococcus

2022-03-26

Abstract excerpt

Calcineurin is an essential virulence factor that is conserved across human fungal pathogens including Cryptococcus neoformans , Aspergillus fumigatus , and Candida albicans . Although an excellent target for antifungal drug development, the serine-threonine phosphatase activity of calcineurin is conserved in mammals and inhibition of this activity results in immunosuppression. FK506 (tacrolimus) is a naturally...

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Literature Corpus work: 4fc693cb-3c27-5cf8-aaab-480641b3305c
DOI: 10.1101/2022.03.25.485831

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Structure-guided synthesis of FK506 and FK520 analogs with increased selectivity exhibit in vivo therapeutic efficacy against CryptococcusDOI 10.1101/2022.03.25.485831Read

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