Article
Molecular characterization of a plant FKBP12 that does not mediate action of FK506 and rapamycin.
The Plant journal : for cell and molecular biology - 1 Aug 1998
Xu Q, Liang S, Kudla J, Luan S
Abstract excerpt
Immuonosuppressive drugs FK506 and rapamycin block a number of signal transduction pathways in eukaryotic systems. The 12 kDa FK506 binding protein (FKBP12) mediates the action of both FK506 and rapamycin against their functional targets. In this report, we cloned, sequenced and characterized a g...
Topics
- Amino Acid Sequence
- Calcineurin
- Cloning, Molecular
- Cysteine
- Disulfides
- Dithiothreitol
- Fabaceae
- Genes, Plant
- Genetic Complementation Test
- Immunophilins
- Immunosuppressive Agents
- Molecular Sequence Data
- Mutation
- Plants, Medicinal
- Protein Binding
- Protein Structure, Tertiary
- Sequence Analysis, DNA
- Sequence Homology, Amino Acid