Article
The yeast FKS1 gene encodes a novel membrane protein, mutations in which confer FK506 and cyclosporin A hypersensitivity and calcineurin-dependent growth.
Gene - 30 Dec 1994
Eng W K, Faucette L, McLaughlin M M, Cafferkey R, Koltin Y, Morris R A, Young P R, Johnson R K, Livi G P
Abstract excerpt
FK506 and cyclosporin A (CsA) are potent immunosuppressive agents that display antifungal activity. They act by blocking a Ca(2+)-dependent signal transduction pathway leading to interleukin-2 transcription. Each drug forms a complex with its cognate cytosolic immunophilin receptor (i.e., FKBP12-FK506 and cyclophilin-CsA) which acts to inhibit the Ca2+/calmodulin-dependent protein phosphatase 2B, or calcineurin...
Topics
- Amino Acid Sequence
- Base Sequence
- Calcineurin
- Calmodulin-Binding Proteins
- Chromosome Mapping
- Chromosomes, Fungal
- Cloning, Molecular
- Cyclosporine
- DNA Primers
- Dose-Response Relationship, Drug