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Article

Crystal structure of PMGL2 esterase from the hormone-sensitive lipase family with GCSAG motif around the catalytic serine.

PloS one - 1 Jan 2020

Boyko Konstantin M, Kryukova Marya V, Petrovskaya Lada E, Nikolaeva Alena Y, Korzhenevsky Dmitry A, Novototskaya-Vlasova Ksenia A, Rivkina Elizaveta M, Dolgikh Dmitry A, Kirpichnikov Mikhail P, Popov Vladimir O

Abstract excerpt

Lipases comprise a large class of hydrolytic enzymes which catalyze the cleavage of the ester bonds in triacylglycerols and find numerous biotechnological applications. Previously, we have cloned the gene coding for a novel esterase PMGL2 from a Siberian permafrost metagenomic DNA library. We have determined the 3D structure of PMGL2 which belongs to the hormone-sensitive lipase (HSL) family and contains a new...

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Identifiers

PMID: 31990908
DOI: 10.1371/journal.pone.0226838
PMCID: PMC6986724

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Source receipt: pubmed, retrieved 7 Sept 2026.

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