Article
Genetic variants associated with susceptibility to psychosis in late-onset Alzheimer's disease families.
Neurobiology of aging - 1 Nov 2015
Barral Sandra, Vardarajan Badri N, Reyes-Dumeyer Dolly, Faber Kelley M, Bird Thomas D, Tsuang Debby, Bennett David A, Rosenberg Roger, Boeve Bradley F, Graff-Radford Neill R, Goate Alison M, Farlow Martin, Lantigua Rafael, Medrano Martin Z, Wang Xinbing, Kamboh M Ilyas, Barmada Mahmud Muhiedine, Schaid Daniel J, Foroud Tatiana M, Weamer Elise A, Ottman Ruth, Sweet Robert A, Mayeux Richard
Abstract excerpt
Psychotic symptoms are frequent in late-onset Alzheimer's disease (LOAD) patients. Although the risk for psychosis in LOAD is genetically mediated, no genes have been identified. To identify loci potentially containing genetic variants associated with risk of psychosis in LOAD, a total of 263 families from the National Institute of Aging-LOAD cohort were classified into psychotic (LOAD+P, n = 215) and...
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