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A Systematic Analysis Reveals Heterogeneous Changes in the Endocytic Activities of Cancer Cells

11 Sept 2015

Abstract excerpt

Metastasis is a multistep process requiring cancer cell signaling, invasion, migration, survival, and proliferation. These processes require dynamic modulation of cell surface proteins by endocytosis. Given this functional connection, it has been suggested that endocytosis is dysregulated in cancer. To test this, we developed In-Cell ELISA assays to measure three different endocytic pathways: clathrin-mediated...

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PMID: 26359453
DOI: 10.1158/0008-5472.can-15-0939

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