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Article

Mechanosensitive activation of CFTR by increased cell volume and hydrostatic pressure but not shear stress.

Biochimica et biophysica acta - 1 Nov 2015

Vitzthum Constanze, Clauss Wolfgang G, Fronius Martin

Abstract excerpt

The cystic fibrosis transmembrane conductance regulator (CFTR) is a Cl(-) channel that is essential for electrolyte and fluid homeostasis. Preliminary evidence indicates that CFTR is a mechanosensitive channel. In lung epithelia, CFTR is exposed to different mechanical forces such as shear stress (Ss) and membrane distention. The present study questioned whether Ss and/or stretch influence CFTR activity (wild...

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Source

Identifiers

PMID: 26357939
DOI: 10.1016/j.bbamem.2015.09.009

Genes

CFTR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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