Article
Capacitance measurements reveal different pathways for the activation of CFTR.
Pflugers Archiv : European journal of physiology - 1 Sept 1999
Weber W M, Cuppens H, Cassiman J J, Clauss W, Van Driessche W
Abstract excerpt
We used the Xenopus laevis oocyte expression system to characterize adenosine 3',5'-cyclic monophosphate (cAMP) activation of the cystic fibrosis transmembrane conductance regulator (CFTR). With conventional two-microelectrode voltage-clamp techniques, we recorded transmembrane conductance (Gm) and membrane current (Im). Using five different sine wave frequencies, we also monitored changes of the plasma membrane...
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