Article
Swelling-activated Ca2+ entry via TRPV4 channel is defective in cystic fibrosis airway epithelia.
The Journal of biological chemistry - 24 Dec 2004
Arniges Maite, Vázquez Esther, Fernández-Fernández José M, Valverde Miguel A
Abstract excerpt
The vertebrate transient receptor potential cationic channel TRPV4 has been proposed as an osmo- and mechanosensor channel. Studies using knock-out animal models have further emphasized the relevance of the TRPV4 channel in the maintenance of the internal osmotic equilibrium and mechanosensation. However, at the cellular level, there is still one important question to answer: does the TRPV4 channel generate the...
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