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Searching High-Order SNP Combinations for Complex Diseases Based on Energy Distribution Difference.

IEEE/ACM transactions on computational biology and bioinformatics - 1 Jan 2000

Ding Xiaojun, Wang Jianxin, Zelikovsky Alex, Guo Xuan, Xie Minzhu, Pan Yi

Abstract excerpt

Single nucleotide polymorphisms, a dominant type of genetic variants, have been used successfully to identify defective genes causing human single gene diseases. However, most common human diseases are complex diseases and caused by gene-gene and gene-environment interactions. Many SNP-SNP interaction analysis methods have been introduced but they are not powerful enough to discover interactions more than three...

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PMID: 26357280
DOI: 10.1109/TCBB.2014.2363459

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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