Article
KITENIN recruits Dishevelled/PKC delta to form a functional complex and controls the migration and invasiveness of colorectal cancer cells.
Gut - 1 Apr 2009
Kho D H, Bae J A, Lee J H, Cho H J, Cho S H, Lee J H, Seo Y-W, Ahn K Y, Chung I J, Kim K K
Abstract excerpt
BACKGROUND AND AIMS: KITENIN was previously reported to promote metastasis in mouse colon tumour models; however, the signalling mechanism of KITENIN at the cellular level was unknown. Here the functional role of KITENIN with respect to colorectal cancer (CRC) cell invasion and its expression in CRC tissues were investigated. METHODS: The effect of KITENIN on cell motility was analysed in a migration and invasion...
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