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Article

A novel gain of function mutant in C-kit gene and its tumorigenesis in nude mice.

World journal of gastroenterology - 7 Dec 2005

Bai Chen-Guang, Liu Xiao-Hong, Xie Qiang, Feng Fei, Ma Da-Lie

Abstract excerpt

AIM: To transfect mutant C-kit cDNA at codon 579 into human embryonic kidney cell line to observe its role in the pathogenesis of gastrointestinal stromal tumor (GIST). METHODS: Eukaryotic expression vectors of pcDNA3-Kit-NW and pcDNA3-Kit-W were constructed. Then pcDNA3-Kit-NW and pcDNA3-Kit-W plasmids were transfected into human embryonic kidney cell line by Lipofectamine. The resistant clone was screened by...

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Identifiers

PMID: 16437655
DOI: 10.3748/wjg.v11.i45.7104
PMCID: PMC4725073

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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