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Article

Receptor tyrosine kinase C-kit promotes a destructive phenotype of FLS in osteoarthritis via intracellular EMT signaling.

Molecular medicine (Cambridge, Mass.) - 23 Mar 2023

Cao Xu, Wu Song, Wang Xinxing, Huang Junjie, Zhang Wenxiu, Liang Chi

Abstract excerpt

BACKGROUND: Chronic inflammation, mainly derived from fibroblast-like synoviocytes (FLSs), plays a central role in the pathomechanism of osteoarthritis (OA). Recently, epithelial-mesenchymal transition (EMT) signaling was found to be activated in OA-derived FLSs with a pro-inflammatory phenotype. However, the role of EMT signaling in regulating FLS function and OA-related inflammation remains unknown. METHODS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36959556
DOI: 10.1186/s10020-023-00633-6
PMCID: PMC10037859

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