Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Toll-Like Receptor 2-Mediated Autophagy Promotes Microglial Cell Death by Modulating the Microglial M1/M2 Phenotype.

Inflammation - 1 Apr 2020

Ma Kun, Guo Jingjing, Wang Guan, Ni Qiuying, Liu Xinjie

Abstract excerpt

Toll-like receptor 2 (TLR2) regulates the innate immune response of microglia during infection via autophagy. Microglial M1/M2 phenotypic switching after infection could serve as a novel pathogenic mechanism for cerebral infection. Hence, it has important implications for the damage and restoration of neurological function. However, the effect of TLR2-mediated autophagic signaling on microglial phenotypic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy
Share to Cell Death
Share to Dose-Response Relationship, Drug

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lipopeptides

Share to Mice, Inbred C57BL

Share to Mice, Knockout

Share to Microglia

Share to Toll-Like Receptor 2

Source

Identifiers

PMID: 31834572
DOI: 10.1007/s10753-019-01152-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Toll-Like Receptor 2-Mediated Autophagy Promotes Microglial Cell Death by Modulating the Microglial M1/M2 Phenotype.PMID 31834572Read ↗

TREM2 modulates microglia phenotypes in the neuroinflammation of Parkinson's disease.Semantic proximity Read ↗

FTY720 Modulates Microglia Toward Anti-inflammatory Phenotype by Suppressing Autophagy via STAT1 Pathway.Semantic proximity Read ↗

Alternatively activated microglia and macrophages in the central nervous system.Semantic proximity Read ↗

Inhibition of the TLR4/NF-κB pathway promotes the polarization of LPS-induced BV2 microglia toward the M2 phenotype.Semantic proximity Read ↗

GSP1-111 Modulates the Microglial M1/M2 Phenotype by Inhibition of Toll-like Receptor 2: A Potential Therapeutic Strategy for Depression.Semantic proximity Read ↗

Role of Microglia Autophagy in Microglia Activation After Traumatic Brain InjurySemantic proximity Read ↗

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases.Semantic proximity Read ↗

Pharmacological Modulation of Functional Phenotypes of Microglia in Neurodegenerative DiseasesSemantic proximity Read ↗

Macrophage and microglia polarization: focus on autophagy-dependent reprogrammingSemantic proximity Read ↗

Continuous injection of high-dose lipopolysaccharide modulates microglia polarization via TREM2 to alter the status of septic miceSemantic proximity Read ↗

Function and phenotype of microglia are determined by toll-like receptor 2/toll-like receptor 4 activation sequence.Semantic proximity Read ↗

Autophagic flux regulates microglial phenotype according to the time of oxygen-glucose deprivation/reperfusion.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.