Article
Genetic Variations in Glutathione Pathway Genes Predict Cancer Recurrence in Patients Treated with Transurethral Resection and Bacillus Calmette-Guerin Instillation for Non-muscle Invasive Bladder Cancer.
Annals of surgical oncology - 1 Nov 2015
Ke Hung-Lung, Lin Jie, Ye Yuanqing, Wu Wen-Jeng, Lin Hui-Hui, Wei Hua, Huang Maosheng, Chang David W, Dinney Colin P, Wu Xifeng
Abstract excerpt
BACKGROUND: Glutathione (GSH) is an important molecule involved in cell detoxification and antioxidation and may affect cancer development or outcome. We hypothesized that genetic variation in the GSH pathway might influence the clinical outcome of patients who have non-muscle invasive bladder cancer (NMIBC). METHODS: A total of 114 single nucleotide polymorphisms (SNPs) in 21 GSH pathway genes were genotyped in...
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