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Article

Genetic polymorphisms, methylation, and expression levels in the GSTP1 and MGMT genes in urothelial bladder tumors.

Gene - 5 Mar 2025

Serpeloni Juliana Mara, Silva Isabely Mayara da, van Helvoort Lengert André, de Souza Marilesia Ferreira, Dos Reis Mariana Bisarro, Kuasne Hellen, Fuganti Paulo Emílio, Cólus Ilce Mara de Syllos

Abstract excerpt

BACKGROUND: Alteration in DNA repair and metabolism genes can affect the maintenance of DNA integrity or xenobiotics metabolism, potentially leading to DNA damage accumulation. The present study investigated the association between polymorphisms in Glutathione S-Transferase Pi 1 (GSTP1, rs1695) and O-6-Methylguanine-DNA Methyltransferase (MGMT, rs2308321) genes with urothelial bladder cancer (UBC) susceptibility...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation
Share to DNA Modification Methylases
Share to DNA Repair Enzymes
Share to Gene Expression Regulation, Neoplastic
Share to Glutathione S-Transferase pi
Share to Promoter Regions, Genetic
Share to Tumor Suppressor Proteins
Share to Urinary Bladder Neoplasms

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Identifiers

PMID: 39706230
DOI: 10.1016/j.gene.2024.149158

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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