Article
Rare Circulating Cells in Familial Waldenström Macroglobulinemia Displaying the MYD88 L265P Mutation Are Enriched by Epstein-Barr Virus Immortalization.
PloS one - 1 Jan 2015
Pertesi Maroulio, Galia Perrine, Nazaret Nicolas, Vallée Maxime, Garderet Laurent, Leleu Xavier, Avet-Loiseau Hervé, Foll Matthieu, Byrnes Graham, Lachuer Joel, McKay James D, Dumontet Charles
Abstract excerpt
The MYD88 L265P is a recurrent somatic mutation in neoplastic cells from patients with Waldenström Macroglobulinemia (WM). We identified the MYD88 L265P mutation in three individuals from unrelated families, but its presence did not explain the disease segregation within these WM pedigrees. We observed the mutation in these three individuals at high allele fractions in DNA extracted from EBV-immortalized...
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