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Article

Nanoscale patterning of STIM1 and Orai1 during store-operated Ca2+ entry.

Proceedings of the National Academy of Sciences of the United States of America - 6 Oct 2015

Perni Stefano, Dynes Joseph L, Yeromin Andriy V, Cahalan Michael D, Franzini-Armstrong Clara

Abstract excerpt

Stromal interacting molecule (STIM) and Orai proteins constitute the core machinery of store-operated calcium entry. We used transmission and freeze-fracture electron microscopy to visualize STIM1 and Orai1 at endoplasmic reticulum (ER)-plasma membrane (PM) junctions in HEK 293 cells. Compared with control cells, thin sections of STIM1-transfected cells possessed far more ER elements, which took the form of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26351694
DOI: 10.1073/pnas.1515606112
PMCID: PMC4603497

Genes

STIM1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Nanoscale patterning of STIM1 and Orai1 during store-operated Ca2+ entry.PMID 26351694Read ↗

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