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Article

ERG11 mutations and expression of resistance genes in fluconazole-resistant Candida albicans isolates.

Archives of microbiology - 1 Nov 2015

Xu Yonghao, Sheng Fang, Zhao Jie, Chen Lamei, Li Chunyang

Abstract excerpt

Azole resistance in the pathogenic yeast Candida albicans poses significant challenges for its antibiotic treatment. The conformational change of the target enzyme 14 alpha-demethylase (Erg11p) due to ERG11 gene mutations is one of the mechanisms resulting in the azole resistance. ERG11 of 23 isolates (8 susceptible and 15 resistant) and 6 standard strains of Candida albicans were amplified and sequenced....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26349561
DOI: 10.1007/s00203-015-1146-8

Genes

CDR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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