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Mutations and/or Overexpressions of ERG4 and ERG11 Genes in Clinical Azoles-Resistant Isolates of Candida albicans.

Microbial drug resistance (Larchmont, N.Y.) - 1 Jul 2017

Feng Wenli, Yang Jing, Xi Zhiqin, Qiao Zusha, Lv Yaping, Wang Yiru, Ma Yan, Wang Yanqing, Cen Wen

Abstract excerpt

OBJECTIVE: We aimed to investigate whether mutations and/or overexpressions of ERG4 and ERG11 genes were involved in drug resistance to azoles in Candida albicans. METHODS: Totally, 34 clinical isolates of C. albicans were included in this study. Antimicrobial susceptibility tests, including 5-fluorocytosine (5-FC), amphotericin B (AMB), fluconazole (FCA), itraconazole (ITR), and voriconazole (VRC), were...

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Identifiers

PMID: 27976986
DOI: 10.1089/mdr.2016.0095

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