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Article

Selected mechanisms of molecular resistance of Candida albicans to azole drugs.

Acta biochimica Polonica - 1 Jan 2015

Gołąbek Karolina, Strzelczyk Joanna Katarzyna, Owczarek Aleksander, Cuber Piotr, Ślemp-Migiel Anna, Wiczkowski Andrzej

Abstract excerpt

A phenomenon of increasing resistance of Candida spp. to azoles has been observed for several years now. One of the mechanisms of lack of sensitivity to azoles is associated with CDR1, CDR2, MRD1 genes (their products are active transport pumps conditioning drug efflux from pathogen's cell), and ERG11 gene (encoding lanosterol 14α-demethylase). Test material was 120 strains of Candida albicans (60 resistant and...

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Share to Antifungal Agents
Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Azoles

Share to Candida albicans

Share to Cytochrome P-450 Enzyme System

Share to Drug Resistance, Fungal

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Source

Identifiers

PMID: 25901298
DOI: 10.18388/abp.2014_940

Genes

CDR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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