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Riplet Ubiquitin Ligase Regulates Innate Antiviral Immune Responses Via Lysine 63-Linked Polyubiquitination of RIG-I and LGP2 and is Essential for Protection Against SARS-CoV-2

2020-09-22

Abstract excerpt

RIG-I, a cytoplasmic viral RNA sensor, is crucial for innate antiviral immune responses; however, there are controversies about regulatory mechanism of RIG-I by several ubiquitin ligases and LGP2. In this study, our genetic data showed that Riplet was a primary ubiquitin ligase for RIG-I activation and could compensate for defective TRIM25 in RIG-I activation, whereas TRIM25 activated RIG-I in a cell-type-specific...

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Literature Corpus work: 2ea2ee9b-f122-5d9c-8416-3b22f97df74c
DOI: 10.2139/ssrn.3677228

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