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Article

NLRX1 Mediates MAVS Degradation To Attenuate the Hepatitis C Virus-Induced Innate Immune Response through PCBP2.

Journal of virology - 1 Dec 2017

Qin Yuwen, Xue Binbin, Liu Chunyan, Wang Xiaohong, Tian Renyun, Xie Qinya, Guo Mengmeng, Li Guangdi, Yang Darong, Zhu Haizhen

Abstract excerpt

Activation of innate immunity is essential for host cells to restrict the spread of invading viruses and other pathogens. However, attenuation or termination of signaling is also necessary for preventing immune-mediated tissue damage and spontaneous autoimmunity. Here, we identify nucleotide binding oligomerization domain (NOD)-like receptor X1 (NLRX1) as a negative regulator of the mitochondrial antiviral...

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Topics

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunity, Innate

Share to Mitochondrial Proteins

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Share to RNA-Binding Proteins

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Source

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Identifiers

PMID: 28956771
DOI: 10.1128/JVI.01264-17
PMCID: PMC5686720

Genes

NLRX1
MAVS
PCBP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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