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Uncovering targets of the Leader protease: Linking RNA ‐mediated pathways and antiviral defense

18 Feb 2021

Abstract excerpt

RNA viruses have developed specialized mechanisms to subvert host RNA-binding proteins (RBPs) favoring their own gene expression. The Leader (L) protein of foot-and-mouth disease virus, a member of the Picornaviridae family, is a papain-like cysteine protease that self-cleaves from the polyprotein. Early in infection, the L protease cleaves the translation initiation factors eIF4GI and eIF4GII, inducing the...

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PMID: 33605051
DOI: 10.1002/wrna.1645

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