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Article

Bidirectional, iterative approach to the structural delineation of the functional "chemoprint" in GPR40 for agonist recognition.

Journal of medicinal chemistry - 28 Jun 2007

Tikhonova Irina G, Sum Chi Shing, Neumann Susanne, Thomas Craig J, Raaka Bruce M, Costanzi Stefano, Gershengorn Marvin C

Abstract excerpt

GPR40, free fatty acid receptor 1 (FFAR1), is a member of the GPCR superfamily and a possible target for the treatment of type 2 diabetes. In this work, we conducted a bidirectional iterative investigation, including computational modeling and site-directed mutagenesis, aimed at delineating amino acid residues forming the functional "chemoprint" of GPR40 for agonist recognition. The computational and experimental...

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Source

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Identifiers

PMID: 17552505
DOI: 10.1021/jm0614782
PMCID: PMC3592210

Genes

FFAR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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