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Article

Discovery of novel agonists and antagonists of the free fatty acid receptor 1 (FFAR1) using virtual screening.

Journal of medicinal chemistry - 14 Feb 2008

Tikhonova Irina G, Sum Chi Shing, Neumann Susanne, Engel Stanislav, Raaka Bruce M, Costanzi Stefano, Gershengorn Marvin C

Abstract excerpt

The G-protein-coupled receptor free fatty acid receptor 1 (FFAR1), previously named GPR40, is a possible novel target for the treatment of type 2 diabetes. In an attempt to identify new ligands for this receptor, we performed virtual screening (VS) based on two-dimensional (2D) similarity, three-dimensional (3D) pharmacophore searches, and docking studies by using the structure of known agonists and our model of...

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Source

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Identifiers

PMID: 18193825
DOI: 10.1021/jm7012425
PMCID: PMC3711565

Genes

FFAR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Discovery of novel agonists and antagonists of the free fatty acid receptor 1 (FFAR1) using virtual screening.PMID 18193825Read ↗

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Free Fatty Acid Receptors (FFARs) In Adipose: Physiological Role and Therapeutic OutlookSemantic proximity Read ↗

Combined Virtual Screening and Substructure Search for Discovery of Novel FABP4 Inhibitors.Semantic proximity Read ↗

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