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Exome of Radiation-induced Rat Mammary Carcinoma Shows Copy-number Losses and Mutations in Human-relevant Cancer Genes.

Anticancer research - 1 Jan 2021

Moriyama Hitomi, Daino Kazuhiro, Ishikawa Atsuko, Imaoka Tatsuhiko, Nishimura Mayumi, Nishimura Yukiko, Takabatake Masaru, Morioka Takamitsu, Inoue Kazumasa, Fukushi Masahiro, Shimada Yoshiya, Kakinuma Shizuko

Abstract excerpt

BACKGROUND/AIM: Our understanding of cancer risk from neutron exposure is limited. We aimed to reveal the characteristics of mammary carcinomas induced by neutrons. MATERIALS AND METHODS: Mammary carcinomas obtained from female Sprague-Dawley rats irradiated at 7 weeks of age with 0.97 Gy neutrons or 4 Gy γ-rays and from non-irradiated rats were classified into luminal and non-luminal subtypes by...

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PMID: 33419799
DOI: 10.21873/anticanres.14751

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