Article
Copy number variations of six and seven α-globin genes in a family with intermedia and major thalassemia phenotypes.
Expert review of hematology - 1 Oct 2015
Farashi Samaneh, Vakili Shadi, Faramarzi Garous Negin, Ashki Mehri, Imanian Hashem, Azarkeivan Azita, Najmabadi Hossein
Abstract excerpt
BACKGROUND: Copy number variations in α-globin genes are results of unequal crossover between homologous segments in the α-globin gene cluster that misalign during the meiosis phase of the gametogenesis process. Reduction or augmentation of α-globin genes leads to imbalance of α/β chains in hemoglobin tetramer and consequently attenuate or worsen the β-thal clinical symptoms, respectively. OBJECTIVE:...
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