Article
Interaction of an α-Globin Gene Triplication with β-Globin Gene Mutations in Iranian Patients with β-Thalassemia Intermedia.
Hemoglobin - 1 Jan 2015
Farashi Samaneh, Bayat Nooshin, Faramarzi Garous Negin, Ashki Mehri, Montajabi Niat Mona, Vakili Shadi, Imanian Hashem, Zeinali Sirous, Najmabadi Hossein, Azarkeivan Azita
Abstract excerpt
The 3.7 kb triplicated α-globin gene (ααα(anti 3.7)) mutation has been found in most populations. It results from an unequal crossover between misaligned homologous segments in the α-globin gene cluster during meiosis. The pathophysiology and clinical severity of β-thalassemia (β-thal) are associated with the degree of α chain imbalance. The excess of α-globin chains plays an important role in the pathophysiology...
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