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Alpha‐globin gene triplication and its effect in beta‐thalassemia carrier, sickle cell trait, and healthy individual

19 Jul 2021

Abstract excerpt

The genotype and phenotype correlation between coinheritance of heterozygous beta-thalassemia with the alpha-globin triplication is unclear. In this study we have investigated and reviewed alpha triplication frequency in beta-thalassemia carriers, sickle cell trait, and healthy individuals and its effect on hematological and phenotypical changes. In this study, 4005 beta-thalassemia carriers, 455 sickle cell...

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PMID: 35844714
DOI: 10.1002/jha2.262

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