Article
A 21 Nucleotide Duplication on the α1- and α2-Globin Genes Involves a Variety of Hypochromic Microcytic Anemias, From Mild to Hb H Disease.
Hemoglobin - 1 Jan 2015
Farashi Samaneh, Faramarzi Garous Negin, Zeinali Fatemeh, Vakili Shadi, Ashki Mehri, Imanian Hashem, Najmabadi Hossein, Azarkeivan Azita, Tamaddoni Ahmad
Abstract excerpt
α-Thalassemia (α-thal) is a common genetic disorder in Iran and many parts of the world. Genetic defects in the α-globin gene cluster can result in α-thal that may develop into a clinical phenotype varying from almost asymptomatic to a lethal hemolytic anemia. Loss of one functional α gene, indicated as heterozygous α(+)-thal, shows minor hematological abnormalities. Homozygosity for α(+)- or heterozygosity for...
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