Article
Frequency of positive XmnIGgamma polymorphism and coinheritance of common alpha thalassemia mutations do not show statistically significant difference between thalassemia major and intermedia cases with homozygous IVSII-1 mutation.
Blood cells, molecules & diseases - 1 Jan 2000
Neishabury Maryam, Azarkeivan Azita, Najmabadi Hossein
Abstract excerpt
From 362 thalassemia cases referred to adult thalassemia clinic of the Iranian blood transfusion organization (IBTO) for genotyping, 103 cases (28.5%) had a common primary disease factor, IVSII-1 mutation in homozygous state. 61 (59.2%) of these individuals represented thalassemia major and 42 (40.8%) thalassemia intermedia clinical phenotype. To re-evaluate our current diagnostic criteria, XmnI(G)gamma...
Topics
- Adolescent
- Adult
- Child
- Cohort Studies
- Homozygote
- Humans
- Iran
- Middle Aged
- Mutation
- Polymorphism, Genetic
- Thalassemia
- Young Adult
- alpha-Thalassemia
- beta-Globins
- beta-Thalassemia