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[Analysis of copy number variations in alpha-globin gene in the cases with combined increased levels of HbF with β thalassemia].

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics - 1 Aug 2015

Liu Siping, Song Lanlin, Xiong Li, Wang Ke, Shen Hong, Zhong Mei

Abstract excerpt

OBJECTIVE: To detect copy number changes of α-globin gene, and analyze molecular mechanism of the impacts of fetal hemoglobin (HbF) levels for α-globin gene copy numbers loss or increase. METHODS: A total of 15 cases with combined increased levels of fetal hemoglobin with β-thalassemia were collected. Firstly, three common α-thalassemia deletions were validated by Gap-PCR. Secondly, the largest deletions of the...

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Identifiers

PMID: 26252098
DOI: 10.3760/cma.j.issn.1003-9406.2015.04.015

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SEA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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