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Article

Targeted deep sequencing identifies rare loss-of-function variants in IFNGR1 for risk of atopic dermatitis complicated by eczema herpeticum.

The Journal of allergy and clinical immunology - 1 Dec 2015

Gao Li, Bin Lianghua, Rafaels Nicholas M, Huang Lili, Potee Joseph, Ruczinski Ingo, Beaty Terri H, Paller Amy S, Schneider Lynda C, Gallo Rich, Hanifin Jon M, Beck Lisa A, Geha Raif S, Mathias Rasika A, Barnes Kathleen C, Leung Donald Y M

Abstract excerpt

BACKGROUND: A subset of atopic dermatitis is associated with increased susceptibility to eczema herpeticum (ADEH+). We previously reported that common single nucleotide polymorphisms (SNPs) in the IFN-γ (IFNG) and IFN-γ receptor 1 (IFNGR1) genes were associated with the ADEH+ phenotype. OBJECTIVE: We sought to interrogate the role of rare variants in interferon pathway genes for the risk of ADEH+. METHODS: We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26343451
DOI: 10.1016/j.jaci.2015.06.047
PMCID: PMC4679503

Genes

IFNGR1
IFNG
IFNAR1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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