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Article

Human atopic dermatitis complicated by eczema herpeticum is associated with abnormalities in IFN-γ response.

The Journal of allergy and clinical immunology - 1 Apr 2011

Leung Donald Y M, Gao Pei-Song, Grigoryev Dmitry N, Rafaels Nicholas M, Streib Joanne E, Howell Michael D, Taylor Patricia A, Boguniewicz Mark, Canniff Jennifer, Armstrong Brian, Zaccaro Daniel J, Schneider Lynda C, Hata Tissa R, Hanifin Jon M, Beck Lisa A, Weinberg Adriana, Barnes Kathleen C

Abstract excerpt

BACKGROUND: The basis for increased susceptibility of patients with atopic dermatitis (AD) to develop disseminated viral skin infections such as eczema herpeticum (AD with a history of eczema herpeticum, ADEH(+)) is poorly understood. OBJECTIVE: We sought to determine whether subjects with AD prone to disseminated viral skin infections have defects in their IFN responses. METHODS: GeneChip profiling was used to...

Topics

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Dermatitis, Atopic
Enzyme-Linked Immunosorbent Assay
Gene Expression Profiling
Interferon-gamma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Interferon gamma Receptor

Oligonucleotide Array Sequence Analysis

Receptors, Interferon

Source

Open in PubMed Open full text

Identifiers

PMID: 21458658
DOI: 10.1016/j.jaci.2011.02.010
PMCID: PMC3074534

Genes

IFNGR1
IFNG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Human atopic dermatitis complicated by eczema herpeticum is associated with abnormalities in IFN-γ response.PMID 21458658Read ↗

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