Whole genome sequencing identifies novel genetic mutations in patients with eczema herpeticum.

doi:10.1111/all.14762

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Article

Whole genome sequencing identifies novel genetic mutations in patients with eczema herpeticum.

Allergy - 1 Aug 2021

Bin Lianghua, Malley Claire, Taylor Patricia, Preethi Boorgula Meher, Chavan Sameer, Daya Michelle, Mathias Malaika, Shankar Gautam, Rafaels Nicholas, Vergara Candelaria, Potee Joseph, Campbell Monica, Hanifin Jon M, Simpson Eric, Schneider Lynda C, Gallo Richard L, Hata Tissa, Paller Amy S, De Benedetto Anna, Beck Lisa A, Ong Peck Y, Guttman-Yassky Emma, Richers Brittany, Baraghoshi David, Ruczinski Ingo, Barnes Kathleen C, Leung Donald Y M, Mathias Rasika A

Abstract excerpt

BACKGROUND: Eczema herpeticum (EH) is a rare complication of atopic dermatitis (AD) caused by disseminated herpes simplex virus (HSV) infection. The role of rare and/or deleterious genetic variants in disease etiology is largely unknown. This study aimed to identify genes that harbor damaging genetic variants associated with HSV infection in AD with a history of recurrent eczema herpeticum (ADEH+). METHODS: Whole...

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PMID: 33548076
DOI: 10.1111/all.14762
PMCID: PMC8978872

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