Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Twist promotes reprogramming of glucose metabolism in breast cancer cells through PI3K/AKT and p53 signaling pathways.

Oncotarget - 22 Sept 2015

Yang Li, Hou Yixuan, Yuan Jie, Tang Shifu, Zhang Hailong, Zhu Qing, Du Yan-e, Zhou Mingli, Wen Siyang, Xu Liyun, Tang Xi, Cui Xiaojiang, Liu Manran

Abstract excerpt

Twist, a key regulator of epithelial-mesenchymal transition (EMT), plays an important role in the development of a tumorigenic phenotype. Energy metabolism reprogramming (EMR), a newly discovered hallmark of cancer cells, potentiates cancer cell proliferation, survival, and invasion. Currently little is known about the effects of Twist on tumor EMR. In this study, we found that glucose consumption and lactate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epithelial-Mesenchymal Transition
Share to Focal Adhesion Kinase 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Integrin beta1

Share to Lactic Acid

Share to Phosphatidylinositol 3-Kinase

Share to Phosphoinositide-3 Kinase Inhibitors

Share to TOR Serine-Threonine Kinases

Share to Twist-Related Protein 1

Source

Open in PubMed Open full text

Identifiers

PMID: 26342198
DOI: 10.18632/oncotarget.4697
PMCID: PMC4694864

Genes

LDHA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Twist promotes reprogramming of glucose metabolism in breast cancer cells through PI3K/AKT and p53 signaling pathways.PMID 26342198Read ↗

Twist-Induced Epithelial-to-Mesenchymal Transition Confers Specific Metabolic and Mitochondrial AlterationsSemantic proximity Read ↗

LKB1 is a central regulator of tumor initiation and pro-growth metabolism in ErbB2-mediated breast cancerSemantic proximity Read ↗

miR-526b dysregulates glucose metabolism via the COX2/EP4 pathwaySemantic proximity Read ↗

YAP1-TEAD1-Glut1 axis dictates the oncogenic phenotypes of breast cancer cells by modulating glycolysis.Semantic proximity Read ↗

TP53 mutation hits energy metabolism and increases glycolysis in breast cancer.Semantic proximity Read ↗

Glucose Metabolic Reprogramming in Thyroid Cancer: Underlying Molecular Mechanisms and Links to Progression and Treatment.Semantic proximity Read ↗

Is Lactate an Oncometabolite? Evidence Supporting a Role for Lactate in the Regulation of Transcriptional Activity of Cancer-Related Genes in MCF7 Breast Cancer CellsSemantic proximity Read ↗

Exosomal circSIPA1L3-mediated intercellular communication contributes to glucose metabolic reprogramming and progression of triple negative breast cancerSemantic proximity Read ↗

The role of glycolysis and lactate in the induction of tumor-associated macrophages immunosuppressive phenotype.Semantic proximity Read ↗

Inhibition of Aerobic Glycolysis Represses Akt/mTOR/HIF-1α Axis and Restores Tamoxifen Sensitivity in Antiestrogen-Resistant Breast Cancer Cells.Semantic proximity Read ↗

Polyol Pathway Links Glucose Metabolism to the Aggressiveness of Cancer CellsSemantic proximity Read ↗

p53 Promotes chemoresponsiveness by regulating hexokinase II gene transcription and metabolic reprogramming in epithelial ovarian cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.