Article
TP53 mutation hits energy metabolism and increases glycolysis in breast cancer.
Oncotarget - 11 Oct 2016
Harami-Papp Hajnalka, Pongor Lőrinc S, Munkácsy Gyöngyi, Horváth Gergő, Nagy Ádám M, Ambrus Attila, Hauser Péter, Szabó András, Tretter László, Győrffy Balázs
Abstract excerpt
Promising new hallmarks of cancer is alteration of energy metabolism that involves molecular mechanisms shifting cancer cells to aerobe glycolysis. Our goal was to evaluate the correlation between mutation in the commonly mutated tumor suppressor gene TP53 and metabolism. We established a database comprising mutation and RNA-seq expression data of the TCGA repository and performed receiver operating...
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