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Article

Inhibition of Aerobic Glycolysis Represses Akt/mTOR/HIF-1α Axis and Restores Tamoxifen Sensitivity in Antiestrogen-Resistant Breast Cancer Cells.

PloS one - 1 Jan 2015

Woo Yu Mi, Shin Yubin, Lee Eun Ji, Lee Sunyoung, Jeong Seung Hun, Kong Hyun Kyung, Park Eun Young, Kim Hyoung Kyu, Han Jin, Chang Minsun, Park Jong-Hoon

Abstract excerpt

Tamoxifen resistance is often observed in the majority of estrogen receptor-positive breast cancers and it remains as a serious clinical problem in breast cancer management. Increased aerobic glycolysis has been proposed as one of the mechanisms for acquired resistance to chemotherapeutic agents in breast cancer cells such as adriamycin. Herein, we report that the glycolysis rates in LCC2 and...

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Identifiers

PMID: 26158266
DOI: 10.1371/journal.pone.0132285
PMCID: PMC4497721

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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